Phospholipid bilayer permeability of .BETA.-lactam antibiotics.
نویسندگان
چکیده
منابع مشابه
Beta-Lactam Antibiotics and Vancomycin Beta-lactam antibiotics
Anti-bacterial drugs have “selective toxicity”, that is they interact with a target present on the bacterial cell, the prokaryote, that is not present in the mammalian host, the eukaryote. For the ß-lactam drugs, this target is the cell wall. Mammalian cells lack cell walls, which for the bacteria are a critically important barrier protecting the organism from not only the vagaries of osmotic s...
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Humans have been plagued with the threat of bacterial infection since before the dawn of recorded history, and have thus always had a keen interest in finding a suitable treatment for these maladies. In the early part of the 19th century, colonial Americans were fearful of death by bacterial infections that are now considered routine, and usually inquired about one another's health in their let...
متن کاملCross-reactivity of beta-lactam antibiotics.
BUMC PROCEEDINGS 2001;14:106–107 D uring a drug history, the most common drug allergies cited are those experienced after the administration of a penicillin, with a reported allergy incidence of 1% to 10% in patients who receive drugs in this class (1). Penicillins, as well as other beta-lactam antibiotics such as cephalosporins, carbapenems, and monobactams, contain a beta-lactam ring (2). The...
متن کاملFunction of the outer membrane of Escherichia coli as a permeability barrier to beta-lactam antibiotics.
On the basis of a simple theoretical model, the ease of penetration of beta-lactam antibiotics through the outer membrane of Escherichia coli was measured. The cell envelope was found to act as a diffusion barrier to both penicillins and cephalosporins. The validity of the model and the cooperative action of cell-bound beta-lactamase and outer membrane were further verified by comparing calcula...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1982
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.35.1692